Stereodynamic Chemosensors

Categories: “Medical and Research Devices“

Reference #: 2013-039

OTC Contact: Sharon E. Pula, Esq. (Directory Information | Send a Message)

Description

An analytical method of determining  stereoisomeric excess and/or concentration and/or absolute configuration of chiral compounds in a sample of chiral analytes that can exist in stereoisomeric (enantiomeric or diasteromeric) forms using stereodynamic ligand and metal complexes.

Applications

• Evaluate high-throughput reactions whose desired product is chiral;
• Determine the stereoisomeric excess of the desired product, thus indicating the stereoselectivity of the reaction
• Determine the concentration of the total product and/or the desired isomer, thus indicating the overall or individual yield of the reaction
• High-throughput screening of chiral compounds to sense enantiomer presence, concentration and configuration Optimization of reaction parameters, allowing the development, amplification and modification of asymmetric catalysts for instance
• Enantiopurity assessment of compound samples.

Advantages

• Provides for fast concentration and stereoisomeric excess
• High-throughput method accelerates the discovery progress
• Inexpensive way of sensing chirality in a large variety of chiral compounds
• Minimizes waste production
• Fluorescent or UV active  moiety for optical sensing

Stage of Development

Reduced to practice

Inventors

Christian Wolf
Keith Bentley
 

Patent Status

Issued – US Patent No. 10,012,627