Stable human primary patient-derived astrocyte cell cultures from fetal and adult brain tissue

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Categories: “Diagnostics” “Research Tools

Reference #: 2017-048

OTC Contact: Ruchika Nijhara Ph.D., MBA, Director (Directory Information | Send a Message)


Astrocyte cultures, conditionally reprogrammed to be ‘immortal’ with unlimited expansion potential.

To date, creating immortalized cell lines typically requires significant genetic manipulation that alters the phenotypic biology of cells, a problem that is exacerbated with multiple passages. Propagation of unaltered primary astrocyte cell lines is limited to 5-8 passages and these are derived solely from fetal brain. Georgetown investigators have developed a unique media composition which allow normal astrocytes from both fetal and adult origin to proliferate over a long time without any genetic manipulation. 



Stage of Development

The cultured astrocytes validates to retain key biomarkers of the cell type.  Functional characterization studies ongoing and to be soon completed. 


Seema Agarwal

Brent Harris

Richard Schlegel