RACK1 Inhibitors for Treatment of Viral Infections

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Categories: “”Viruses, Chronic & Infectious Diseases” 

Reference #: 2015-035

OTC Contact: Ruchika Nijhara Ph.D., MBA (Directory Information | Send a Message)


Viruses require host factors to translate their transcripts and so targeting the host factor (s) offers an opportunity to develop broad spectrum anti-viral drugs. The receptor for Activated C Kinase I (RACK1) is one such host protein that some viruses use to translate their mRNAs using a viral mRNA secondary structure known as the Internal Ribosomal Entry Site (IRES). The present invention pertains to compounds and methods of treating infections from viruses containing a genome coding IRES by administering such RACK1 inhibitors that block IRES mediated translation of such viruses.



Stage of Development

Proof of concept demonstrated in vitro. The lead compound did not demonstrate any major toxicity linked to RACK1 inhibition.


Hemayet Ullah
Sivanesan Dakshanamurthy

Patent Status

Patent pending