Quantitative Chirality And Concentration Sensing Of Chiral Analytes Using Quinones, (Hetero)Aryl Isocyanates, And/Or (Hetero)Aryl Isothiocyanates
Reference #: 2021-019
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Georgetown University researchers have developed an analytical method for the determination of the absolute configuration and/or the concentration/yield and/or the enantiomeric/diastereomeric composition of a chiral analyte in the sample. The method utilizes the formation of a covalent bond between a quinone, (hetero)aryl isocyanate, and/or (hetero)aryl isothiocyanate probe and an analyte in a sample. Chiroptical and/or optical spectroscopic signal techniques are used in the analysis of the probe–analyte derivatives.
- Methods can be used to determine the enantiomeric/diastereomeric composition of the desired product, thus indicating the stereoselectivity of the reaction.
- Methods can be used to determine the concentration of the total product and/or the desired isomer, thus indicating the overall or individual yield of the reaction.
- Methods allow for the determination of two or three of the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.
- Method can also be used to determine the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.
- The methods provide rapid and convenient tools for simultaneously determining the concentration as well as the enantiomeric composition and/or the diastereomeric composition and/or absolute configuration of chiral analytes.
- These methods may be particularly useful for evaluating high-throughput reactions whose desired product is chiral.
STAGE OF DEVELOPMENT
Reduced to practice
PCT patent application pending
Christian Wolf, PhD., Eryn Nelson, Jeffrey S.S.K. Formen