Quantitative Chirality And Concentration Sensing Of Chiral Analytes Using Quinones, (Hetero)Aryl Isocyanates, And/Or (Hetero)Aryl Isothiocyanates
Categories: “Chemistry“
Reference #: 2021-019
OTC Contact: Sharon E. Pula, J.D., M.S. (Directory Information | Send a Message)
Contracts Guide
Disclose Your Invention
MTA/CDA Assistance
COVID-19 Related Agreements
Main Campus Research
Office of Sponsored Research
Education Links
Connect with Industry
Technologies for Licensing
Industry Collaboration Opportunities
Research and Clinical Trials
INVENTION
Georgetown University researchers have developed an analytical method for the determination of the absolute configuration and/or the concentration/yield and/or the enantiomeric/diastereomeric composition of a chiral analyte in the sample. The method utilizes the formation of a covalent bond between a quinone, (hetero)aryl isocyanate, and/or (hetero)aryl isothiocyanate probe and an analyte in a sample. Chiroptical and/or optical spectroscopic signal techniques are used in the analysis of the probe–analyte derivatives.
APPLICATION
- Methods can be used to determine the enantiomeric/diastereomeric composition of the desired product, thus indicating the stereoselectivity of the reaction.
- Methods can be used to determine the concentration of the total product and/or the desired isomer, thus indicating the overall or individual yield of the reaction.
- Methods allow for the determination of two or three of the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.
- Method can also be used to determine the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.
ADVANTAGES
- The methods provide rapid and convenient tools for simultaneously determining the concentration as well as the enantiomeric composition and/or the diastereomeric composition and/or absolute configuration of chiral analytes.
- These methods may be particularly useful for evaluating high-throughput reactions whose desired product is chiral.
STAGE OF DEVELOPMENT
Reduced to practice
PATENT STATUS
PCT patent application pending
INVENTORS
Christian Wolf, PhD., Eryn Nelson, Jeffrey S.S.K. Formen