Quantitative Chirality And Concentration Sensing Of Chiral Analytes Using Quinones, (Hetero)Aryl Isocyanates, And/Or (Hetero)Aryl Isothiocyanates

Categories: “Chemistry“

Reference #: 2021-019

OTC Contact: Sharon E. Pula, J.D., M.S. (Directory Information | Send a Message)

INVENTION

Georgetown University researchers have developed an analytical method for the determination of the absolute configuration and/or the concentration/yield and/or the enantiomeric/diastereomeric composition of a chiral analyte in the sample.  The method utilizes the formation of a covalent bond between a quinone, (hetero)aryl isocyanate, and/or (hetero)aryl isothiocyanate probe and an analyte in a sample.  Chiroptical and/or optical spectroscopic signal techniques are used in the analysis of the probe–analyte derivatives. 

APPLICATION

• Methods can be used to determine the enantiomeric/diastereomeric composition of the desired product, thus indicating the stereoselectivity of the reaction. 
• Methods can be used to determine the concentration of the total product and/or the desired isomer, thus indicating the overall or individual yield of the reaction.
• Methods allow for the determination of two or three of the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.
• Method can also be used to determine the absolute configuration, the concentration, the enantiomeric composition, and the diastereomeric composition of the analyte.

ADVANTAGES

• The methods provide rapid and convenient tools for simultaneously determining the concentration as well as the enantiomeric composition and/or the diastereomeric composition and/or absolute configuration of chiral analytes.
• These methods may be particularly useful for evaluating high-throughput reactions whose desired product is chiral.  

STAGE OF DEVELOPMENT

Reduced to practice

PATENT STATUS

PCT patent application pending

INVENTORS

Christian Wolf, PhD., Eryn Nelson, Jeffrey S.S.K. Formen