Quantitative Chirality And Concentration Sensing Of Chiral Analytes Using Quinones, (Hetero)Aryl Isocyanates, And/Or (Hetero)Aryl Isothiocyanates

Categories: “Chemistry

Reference #: 2021-019

OTC Contact: Sharon E. Pula, J.D., M.S. (Directory Information | Send a Message)

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INVENTION

Georgetown University researchers have developed an analytical method for the determination of the absolute configuration and/or the concentration/yield and/or the enantiomeric/diastereomeric composition of a chiral analyte in the sample.  The method utilizes the formation of a covalent bond between a quinone, (hetero)aryl isocyanate, and/or (hetero)aryl isothiocyanate probe and an analyte in a sample.  Chiroptical and/or optical spectroscopic signal techniques are used in the analysis of the probe–analyte derivatives. 

APPLICATION

ADVANTAGES

STAGE OF DEVELOPMENT

Reduced to practice

PATENT STATUS

PCT patent application pending

INVENTORS

Christian Wolf, PhD., Eryn Nelson, Jeffrey S.S.K. Formen