A Novel Cell Transplantation Platform
Reference #: 2018-002
A cell transplantation method that utilizes a sealed transplantation space – wherein decellularized human amniotic membranes provides human islet grafts with a extracellular metrics-like support, and human amniotic epithelial cells (HAECs) improve new blood vessel formation due to their stem cell-like features- are attached to the surface of a visceral organ in order to restore or increase normal function.
- Human islet transplantation including auto, allo, and xenografts. Additionally, this platform can be used with other types of cell transplantation such as hepatocytes
- Solves the issue of poor human islet engraftment
- Avoids thrombosis and hepatic tissue ischemia caused by islet entrapment in liver sinusoids that leads to sinusoidal endothelial cell activation and functional impairment associated with intraportal islet infusion
- Use of HAECs expedites the revascularization of islet graft to the host due to their stem cell like features
Stage of Development
Animal studies and preliminary in vitro testing.