Ultrahigh Density Tissue Microarrays

Categories: “Diagnostics

Reference #: 2003-042

OTC Contact: Sharon E. Pula, M.S., J.D., Associate Director (Directory Information | Send a Message)


Georgetown University is seeking a partner interested in the development and commercialization of novel sectioning and bonding technology to make ultrahigh density tissue microarrays of solid tissue samples. Currently, tissue sample microarrays are constructed using a core-based sampling method. Unfortunately, since each tissue core can be of variable depth and quality, the core-based method rarely results in microarrays with greater than 150 good quality samples. Further, the variable depth of the core samples can lead to considerable loss of sample representation. Investigators working at Georgetown University have developed a new method that utilizes cutting edge matrix assembly (CEMA) to produce arrays of samples with precisely defined dimensions. As a result, tissue microarrays containing over 10,000 samples with equal representation can be constructed. This invention facilitates parallel analyses of large numbers of tissue samples, which is important for high throughput screening of potential drug targets, for example.


This technology encompasses new method for construction of ultrahigh density microarrays of thousands of solid or solidified samples. CEMA allows for improved quality control of tumor tissue arrays and may be particularly useful for large-scale tissue toxicity profiling of multiple drugs and their interactions.


Relevant Publications

“Ultrahigh density microarrays of solid samples.” Nature Methods. 2005, 2, 511-513.

Patent Status

Patents are currently pending in the US, Canada, Europe, and Australia