A Novel Use of the Phytoestrogen Biochanin A in Neuroprotection

Categories: “Other Disorders” “Neurodegenerative Therapeutics

Reference #: 2009-022

OTC Contact: Ruchika Nijhara, PhD, MBA, CLP; Office: (202) 687-3721 (Directory Information | Send a Message)


Neural injury is often an irreversible event that results in lifelong consequences. Therapeutic options to reduce neuronal injury following central or peripheral nervous system disorder or injury, or any other kind of injury, surgery, or chronic neuropathy are necessary to reduce the lifelong effects associated with neuronal toxicity. As it stands, current treatment strategies to reduce neuronal injury have limited effectiveness and adverse side effects. Our invention describes a new use of a naturally occurring dietary supplement, Biochanin A to reduce and/or prevent nerve damage. Georgetown researchers demonstrate that Biochanin A effectively prevents or rescues neuronal injury by modulating p75 NTR expression. The present invention also describes a method of screening agents that modulate neuronal cell death, thereby allowing for cheap and efficient screening of neuroprotective agents.



Stage of Development

Biochanin A has been demonstrated to protect from ibuprofen-induced neuronal injury caused by up-regulation of p75NTR. Proof of principle has been established in an animal model of neuropathic pain.
Relevant Publications

“Biochanin A reduces drug-induced p75NTR expression and enhances cell survival: a new in vitro assay for screening inhibitors of p75NTR expression”. El Touny LH et. al., Rejuvenation Research. 2010; 5: 227-237

“Quercetin promotes functional recovery following acute spinal cord injury”. Schültke E, et. al., J Neurotrauma. 2003 Jun; 20(6): 583-91.

Patent Status

Patent application has been filed.