Next-Generation Sequencing To Identify ABO Blood Group

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Categories: “Medical and Research Devices

Reference #: 2016-033

OTC Contact: Sharon E. Pula, Esq. (Directory Information | Send a Message)


A kit and method for genotyping of both alleles of the glycosyltransferase  gene controlling A, B and O antigens using “next generation sequencing”.  HLA genotyping may also be performed in the same single run, thereby providing more complete information for use in donor selection matching for transplantations and transfusions.




A significant challenge for donor registries is how to identify the factors that are important for unrelated donor selection in a rapid, cost effective manner. HLA assignment is the primary step in making this determination, however there are thousands of HLA alleles and various polymorphisms that occur within them, thus increasing ambiguity and necessitating secondary assays. Next-generation DNA sequencing separates alleles and reduces ambiguity. In addition to HLA testing, ABO typing must also be performed in the donor selection process. The present invention provides for both HLA and ABO allele analysis and typing in a single run.

Stage of Development

Concept development.


Carolyn Hurley
Jennifer Ng-McClelland
Lihua Hou

Patent Status

Utility patent application pending