Reference #: 2003-005
Novel fluorescent molecular sensors can be used rapidly measure the enantiomeric excess of chiral chemical compounds without the need for time consuming chromatography techniques. Many biologically active compounds (flavors, nutrients, agrochemicals, pharmaceutical drugs) are chiral and used in enantiopure form. For example, while one enantiomer of a chiral drug can exhibit the desired pharmacological activity the other enantiomer can be toxic, so accurate measurements of enantio-purity are critical. These sensors utilize fluorescence and UV spectroscopy to allow the quantitative measurement of enantiopurity in chiral molecules. These sensors can be used for high-throughput synthetic screening (HTS) to rapidly detect the enantioselectivity of chemical reaction products and to determine a compound’s stability to racemization under different conditions.
- High-throughput screening of asymmetric reactions
- Differentiating between and detecting/quantifying enantiopurity of a broad range of chiral compounds including carboxylic acids, alcohols, amines, and amides
- An alternative to time consuming chromotagraphic analysis
- Ability to rapidly detect the enantioselectivity of in HTS of asymmetric reactions
- In situ detection allows for the screening of a compound’s stability to racemization.
Stage of Development
Proof of principle and different applications of the technology have been successfully demonstrated with a variety of chiral substrates.
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Xuefeng Mei, Christian Wolf.
US Patent Application entitled, “Chiral 1,8-Diarylnaphthalenes, Methods of Making Them, and Their Use as Sensors” published under US/ 20070276140 on November 26, 2007.