Reference #: 2019-036
Despite successful antiretroviral drug therapy, a subset of HIV positive individuals still display synapto-dendritic simplifications and functional cognitive impairments referred to as HIV-associated neurocognitive disorders (HAND). HIV envelope protein gp120 is a potential contributing factor for loss of synapses seen in a subset of HIV positive individuals who develop HAND. Among mechanisms proposed to explain gp120’s neurotoxicity is the alteration of axonal transport, which relies on acetylation of neuronal tubulin. Gp120-mediated tubulin deacetylation, which is mediated by histone deacetylase 6
(HDAC6), impairs the association of key motor proteins, with the microtubule, and thus damages axonal transport.
Using primary rat neuronal cultures, researchers at Georgetown University’s Department of Neuroscience demonstrated that ACY-1215, a potent and selective HDAC6 inhibitor currently in clinical trials as an anti-cancer therapy (Ricolinostat), prevents gp120-mediated deacetylation of tubulin, as well as gp120-mediated neurite shortening and cell death.
- HDAC6 inhibition as a viable therapeutic strategy to reduce synaptopathy and neuronal damage seen in HAND patients
At present there is no cure for HIV-associated neuronal degeneration (HAND). HDA6 inhibitors are clinically used for cancer and thus this invention proposes a novel therapeutic intervention for HAND
Italo Mocchetti, Ph.D.
Provisional patent application filed