Therapy for Lipomodeling Via Modulation of Neuropeptide Y Receptor
Section: For Industry
Categories: "Other Disorders"
Reference #: 2005-027
OTC Contact: Ruchika Nijhara, Ph.D. (Directory Information | Send a Message)
Description
The present invention provides a non to minimally invasive, bi-directional therapy for reconstructive plastic surgery by remodeling fat and to improve other metabolic parameters such as insulin resistance and other morbidities associated with obesity such as cardiovascular diseases or diabetes. In addition, the invention describes the methods for stabilizing or increasing fat depot and for promoting wound healing. Specifically, the invention is directed to the methods of using Neuropeptide Y receptor (NPY2R) modulators to remodel fat tissue; and offers new opportunities for the treatment and prevention of obesity and metabolic syndrome.
Applications
- Stand alone therapy for fat remodeling of smaller areas
- Adjunct therapy to traditional weight loss techniques.
- Can be used in corrective procedures, for instance, to fill in depression caused by surgical procedures.
- Wound healing
Advantages
- Site-specific application
- Fine tuning of fat tissue possible.
Stage of Development
Proof-of-concept studies done in mice models.Relevant Publications
"Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome." Zukowska Z. et al. Nat Med. 2007 Jul;13(7).
“NPY and NPY receptors in vascular remodeling”; Zukowska Z. et al. Curr Top Med Chem. 2007;7(17):1704-9.
INVENTORS: Zofia Zukowska, Lydia Kuo, Steven Baker, Michael Johnson, Edward Lee.
Patent Status
PCT application entitled “Compositions and Methods for Lipomodeling” published under # WO 2006/133160 on December 14, 2006. Patent pending in US, Europe and Australia.
