Immobilization of Membrane Receptor on HPLC
Section: For Industry
Categories: "Medical & Research Devices"
Reference #: 1998-027
OTC Contact: Ruchika Nijhara, Ph.D. (Directory Information | Send a Message)
Description
The invention provides methods for immobilization of membrane receptors in order to study relative ligand-receptor interactions utilizing Liquid chromatographic systems (LC). The present invention can be used to test the interaction of potential drugs and receptors and also to evaluate possible agents for inhibition of receptor interactions.
Applications
- Study drug activity
- Identify therapeutic targets
- Identify agonists and antagonist that modulates any membrane receptor.
- Offers potential to study dynamic molecular interactions.
- Does not disrupt the tertiary structure of the receptor during its immobilization.
- The receptor binding column can be reused repeatedly.
Advantages
Stage of Development
Validation studies done with different receptorsRelevant Publications
No relevant publications.
INVENTORS: Irving Wainer, and Yanxiao Zhang
Patent Status
US patents 6,139,735 issued on October 31, 2000
