Non-invasive Passive Interstitial Fluid Collector

Categories: "Medical and Research Devices"

Reference #: 2017-001

OTC Contact: Sharon E. Pula, Esq. (Directory Information | Send a Message)

DESCRIPTION

A microfluidic device for non-invasively and passively accessing interstitial fluid (ISF) from a patient.

APPLICATIONS

  • Transdermal collection of ISF from patients
  • Assess presence biomarkers in ISF 

ADVANTAGES

  • Simple, effective, and time efficient way to painlessly collect ISF from a patient
  • Minimally invasive - utilizes microfluidic technology to help in the passive transfer of ISF from the skin surface to a collection port
  • Use of ISF instead of blood or other bodily fluids reduces or eliminates need to denature sample proteins

BACKGROUND

Blood sampling is the most popular choice for clinical testing, primarily because blood surrounds all tissues and organs, collecting metabolic by-products and biomarkers associated with various disease states. ISF may be a more attractive option since it contains the constituents of blood, excluding proteins and molecules above 60 kDa, thus removing the need to denature proteins that might otherwise interfere with clinical tests. ISF has nevertheless been overlooked as a body fluid with diagnostic applications because current methods to harvest ISF are often uncomfortable, time consuming and invasive.

Researchers at Georgetown University have created a device that can utilize ISF as a new body fluid for diagnostic applications. The microfluidic device allows the passive transfer of ISF from the skin’s surface to a collection port, wherefrom standard clinical tests can be performed to diagnostically assess the presence or absence of biomarkers. This convenient, pain-free method can save time both during sample collection and preparation.

STAGE OF DEVELOPMENT

Reduced to practice and tested.

INVENTORS

Makarand Paranjape

PATENT STATUS

U.S. provisional application has been filed.